#Pathogen #Colonization #Resistance in the #Gut and Its Manipulation for Improved Health (Am J Pathol., abstract)

[Source: American Journal of Pathology, full page: (LINK). Abstract, edited.]

Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health

Joseph M. Pickard, Gabriel Núñez∗

Department of Pathology and the Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan

DOI: https://doi.org/10.1016/j.ajpath.2019.03.003



Mammals have coevolved with a large community of symbiotic, commensal, and some potentially pathogenic microbes. The trillions of bacteria and hundreds of species in our guts form a relatively stable community that resists invasion by outsiders, including pathogens. This powerful protective force is referred to as colonization resistance. We discuss the variety of proposed or demonstrated mechanisms that can mediate colonization resistance and some potential ways to manipulate them for improved human health. Instances in which certain bacterial pathogens can overcome colonization resistance are also discussed.


Supported by NIH grants F32DK118800 (J.M.P.), DK091191 (G.N.), and DK095782 (G.N.).

Disclosures: None declared.

The Rous-Whipple Award is given by the American Society for Investigative Pathology (ASIP) to a senior pathologist with a distinguished career in experimental pathology research and continued productivity at the time of the award. Gabriel Núñez, M.D., recipient of the 2019 ASIP Rous-Whipple Award, delivered a lecture entitled “Role of the Microbiota in Host Defense and Inflammatory Disease” on October 21, 2018, at the PISA 2018 Annual Meeting in Ann Arbor, MI.

© 2019 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Keywords: Human; Microbiome.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.