[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Int Med Res. 2019 May 8:300060519845488. doi: 10.1177/0300060519845488. [Epub ahead of print]
Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review.
Wang WH1,2, Erazo EM3, Ishcol MRC4, Lin CY2,3, Assavalapsakul W5, Thitithanyanont A6, Wang SF2,3,7.
Author information: 1 1 Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung. 2 2 Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung. 3 3 Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung. 4 4 Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung. 5 5 Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. 6 6 Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand. 7 7 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung.
H7N9 avian influenza virus (AIV) caused human infections in 2013 in China. Phylogenetic analyses indicate that H7N9 AIV is a novel reassortant strain with pandemic potential. We conducted a systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection in humans. We followed PRISMA guidelines and searched PubMed, Web of Science, and Google Scholar to identify relevant articles published between January 2013 and December 2018. Pathogenesis data indicated that H7N9 AIV belongs to low pathogenic avian influenza, which is mostly asymptomatic in avian species; however, H7N9 induces high mortality in humans. Sporadic human infections have recently been reported, caused by highly pathogenic avian influenza viruses detected in poultry. H7N9 AIVs resistant to adamantine and oseltamivir cause severe human infection by rapidly inducing progressive acute community-acquired pneumonia, multiorgan dysfunction, and cytokine dysregulation; however, mechanisms via which the virus induces severe syndromes remain unclear. An H7N9 AIV vaccine is lacking; designs under evaluation include synthesized peptide, baculovirus-insect system, and virus-like particle vaccines. Molecular diagnosis of H7N9 AIVs is suggested over conventional assays, for biosafety reasons. Several advanced or modified diagnostic assays are under investigation and development. We summarized virus-induced pathogenesis, vaccine development, and current diagnostic assays in H7N9 AIVs.
KEYWORDS: H7N9; epidemiology; pathogenesis; reassortment; review; vaccine
PMID: 31068040 DOI: 10.1177/0300060519845488
Keywords: H7N9; Avian Influenza; Human; Poultry.