Hemagglutination Inhibition #Antibody #Response Following #Influenza A #H1N1pdm09 Virus Natural #Infection: A Cross-Sectional Study from Thirthahalli, #Karnataka, #India (Viral Immunol., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Viral Immunol. 2019 May 9. doi: 10.1089/vim.2019.0010. [Epub ahead of print]

Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection: A Cross-Sectional Study from Thirthahalli, Karnataka, India.

Alladi CSH1, Jagadesh A1, Prabhu SG1, Arunkumar G1.

Author information: 1 Manipal Centre for Virus Research, Manipal Academy of Higher Education (MAHE), Manipal, India.



Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A(H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer was observed in 100% of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.

KEYWORDS: hemagglutination-inhibition assay; immune response; influenza virus; pre-existing antibodies

PMID: 31070522 DOI: 10.1089/vim.2019.0010

Keywords: Pandemic Influenza; H1N1pdm09; Serology; India.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.