#Genetics and #pathogenicity of #H5N6 highly pathogenic #avian #influenza viruses isolated from #wildbirds and a #chicken in #Japan during winter 2017-2018 (Virology, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Virology. 2019 May 2;533:1-11. doi: 10.1016/j.virol.2019.04.011. [Epub ahead of print]

Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017-2018.

Mine J1, Uchida Y1, Nakayama M1, Tanikawa T1, Tsunekuni R1, Sharshov K2, Takemae N1, Sobolev I2, Shestpalov A2, Saito T3.

Author information: 1 Division of Transboundary Animal Disease, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan; Thailand-Japan Zoonotic Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok, 10900, Thailand. 2 Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. 3 Division of Transboundary Animal Disease, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan; Thailand-Japan Zoonotic Diseases Collaboration Center, Kasetklang, Chatuchak, Bangkok, 10900, Thailand; United Graduate School of Veterinary Sciences, Gifu University, 1-1, Yanagito, Gifu, Gifu, 501-1112, Japan. Electronic address: taksaito@affrc.go.jp.

 

Abstract

An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were genetically similar to clade 2.3.4.4.B H5N8 HPAIVs in Europe during Winter 2016-2017, and Neuraminidase (NA) genes of the poultry and wild bird isolates were gained through distinct reassortments with AIVs that were estimated to have circulated possibly in Siberia during Summer 2017 and Summer 2016, respectively. Lethal infectious dose to chickens was similar between the poultry and wild-bird isolates. H5N6 HPAIVs during Winter 2017-2018 in Japan had higher 50% chicken lethal doses and lower transmission efficiency than the H5Nx HPAIVs that caused previous outbreaks in Japan, thus explaining in part why cases during the 2017-2018 outbreak were sporadic.

Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS: Animal RNA virus; H5N6 highly pathogenic avian influenza; Pathogenicity; Phylogeny

PMID: 31071540 DOI: 10.1016/j.virol.2019.04.011

Keywords: Avian Influenza; H5N6; H5N8; Wild Birds; Poultry; Japan.

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Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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