[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Open Forum Infect Dis. 2019 Mar 7;6(4):ofz106. doi: 10.1093/ofid/ofz106. eCollection 2019 Apr.
Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.
Washburn ML1, Crosby R2, Remlinger K2, Wang F1, Creech D1.
Author information: 1 GlaxoSmithKline, Upper Providence, Pennsylvania. 2 GlaxoSmithKline, Research Triangle Park, North Carolina.
Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.
KEYWORDS: CXCR2 antagonist; biomarker; influenza; neutrophils
PMID: 31041337 PMCID: PMC6483135 DOI: 10.1093/ofid/ofz106
Keywords: Seasonal Influenza; Antivirals; Oseltamivir; Danirixin; Animal models.