Therapeutically Attenuating #Neutrophil Recruitment With a #CXCR2 #Antagonist in Combination With #Oseltamivir Ameliorates #Influenza-Induced #Lung Injury and Disease (Open Forum Infect Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Open Forum Infect Dis. 2019 Mar 7;6(4):ofz106. doi: 10.1093/ofid/ofz106. eCollection 2019 Apr.

Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.

Washburn ML1, Crosby R2, Remlinger K2, Wang F1, Creech D1.

Author information: 1 GlaxoSmithKline, Upper Providence, Pennsylvania. 2 GlaxoSmithKline, Research Triangle Park, North Carolina.



Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.

KEYWORDS: CXCR2 antagonist; biomarker; influenza; neutrophils

PMID: 31041337 PMCID: PMC6483135 DOI: 10.1093/ofid/ofz106

Keywords: Seasonal Influenza; Antivirals; Oseltamivir; Danirixin; Animal models.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum ( in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.