Co-circulation of genetically distinct highly pathogenic #avian #influenza A clade 2.3.4.4 (#H5N6) viruses in wild #waterfowl and #poultry in #Europe and East #Asia, 2017-18 (Virus Evol., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Virus Evol. 2019 Apr 22;5(1):vez004. doi: 10.1093/ve/vez004. eCollection 2019 Jan.

Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017-18.

Poen MJ1, Venkatesh D2, Bestebroer TM1, Vuong O1, Scheuer RD1, Oude Munnink BB1, de Meulder D1, Richard M1, Kuiken T1, Koopmans MPG1, Kelder L3, Kim YJ4, Lee YJ4, Steensels M5, Lambrecht B5, Dan A6, Pohlmann A7, Beer M7, Savic V8, Brown IH9, Fouchier RAM1, Lewis NS9,10.

Author information: 1 Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands. 2 Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. 3 Staatsbosbeheer, Amersfoort, the Netherlands. 4 Avian Influenza Research and Diagnostic Division, Animal and Plant Quarantine Agency, Republic of Korea. 5 Avian Virology and Immunology, Sciensano, Brussels, Belgium. 6 Veterinary Diagnostics Directorate, Budapest, Hungary. 7 Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Insel Riems, Germany. 8 Croatian Veterinary Institute, Zagreb, Croatia. 9 OIE/FAO/EURL International Reference Laboratory for Avian Influenza, Swine Influenza and Newcastle Disease, Animal and Plant Health Agency (APHA)-Weybridge, Addlestone, Surrey, UK. 10 Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.

 

Abstract

Highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4 viruses were first introduced into Europe in late 2014 and re-introduced in late 2016, following detections in Asia and Russia. In contrast to the 2014-15 H5N8 wave, there was substantial local virus amplification in wild birds in Europe in 2016-17 and associated wild bird mortality, with evidence for occasional gene exchange with low pathogenic avian influenza (LPAI) viruses. Since December 2017, several European countries have again reported events or outbreaks with HPAI H5N6 reassortant viruses in both wild birds and poultry, respectively. Previous phylogenetic studies have shown that the two earliest incursions of HPAI H5N8 viruses originated in Southeast Asia and subsequently spread to Europe. In contrast, this study indicates that recent HPAI H5N6 viruses evolved from the H5N8 2016-17 viruses during 2017 by reassortment of a European HPAI H5N8 virus and wild host reservoir LPAI viruses. The genetic and phenotypic differences between these outbreaks and the continuing detections of HPAI viruses in Europe are a cause of concern for both animal and human health. The current co-circulation of potentially zoonotic HPAI and LPAI virus strains in Asia warrants the determination of drivers responsible for the global spread of Asian lineage viruses and the potential threat they pose to public health.

KEYWORDS: H5N6; avian influenza; emerging diseases; highly pathogenic avian influenza; phylogeny; virology

PMID: 31024736 PMCID: PMC6476160 DOI: 10.1093/ve/vez004

Keywords: Avian Influenza; H5N6; H5N8; Reassortant Strain; Poultry; Wild Birds; European Region; Asia Region.

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gimi69

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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