[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]
Detection in Greece of a clinical Enterococcus faeciumisolate carrying the novel oxazolidinone resistance gene poxtA
Costas C Papagiannitsis, Katerina Tsilipounidaki, Ergina Malli, Efi Petinaki
Journal of Antimicrobial Chemotherapy, dkz155, https://doi.org/10.1093/jac/dkz155
Published: 22 April 2019
Oxazolidinones possess potent activity against Gram-positive pathogens such as VRE. Soon after their introduction into clinical practice, linezolid-resistant enterococcal isolates were reported.1 Resistance of enterococci to oxazolidines is mainly associated with mutations in 23S rRNA genes and L3 and L4 ribosomal proteins.2 Additionally, transferable resistance determinants including the cfr, optrAand poxtA genes have also emerged.3–5 Here we report, to the best of our knowledge, the first detection of a poxtA-positive Enterococcus faecium strain isolated in Greece.
…E. faecium isolate (Efa-955) was recovered, in 2018, from a urine sample of a patient treated in the University Hospital…
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Keywords: Antibiotics; Drugs Resistance; Linezolid; Enterococcus faecium; Greece.