[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Transbound Emerg Dis. 2019 Mar;66(2):842-851. doi: 10.1111/tbed.13093. Epub 2019 Jan 5.
Emergence and adaptation of H3N2 canine influenza virus from avian influenza virus: An overlooked role of dogs in interspecies transmission.
He W1, Li G1, Zhu H2, Shi W3, Wang R1, Zhang C1, Bi Y4,5, Lai A6, Gao GF4,5, Su S1.
Author information: 1 MOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China. 2 MRC-University of Glasgow Centre for Virus Research, Glasgow, UK. 3 Institute of Pathogen Biology, Taishan Medical College, Taian, China. 4 Chinese Center for Disease Control and Prevention (China CDC), National Institute for Viral Disease Control and Prevention, Beijing, China. 5 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. 6 College of Natural, Applied, and Health Sciences, Kentucky State University, Frankfort, Kentucky, USA.
H3N2 canine influenza virus (CIV) originated from avian species and emerged in dogs in Asia around 2005 where it became enzootic before reaching the USA in 2015. To investigate the key aspects of the evolution of H3N2 CIV regarding its emergence and adaptation in the canine host, we conducted an extensive analysis of all publicly available H3N2 CIV sequences spanning a 10-year period. We believe that H3N2 AIVs transferred to canines around 2002-2004. Furthermore, H3N2 CIVs could be divided into seven major clades with strong geographic clustering and some changed sites evidence of adaptive evolution. Most notably, the dN/dS of each H3N2 CIVs segment was higher than the correspondent of H3N2 AIVs and the U content of HA and NA was increasing over time, suggesting the idea that this avian-origin virus may be gradually adapting to the host. Our results provide a framework to elucidate a general mechanism for emergence of novel influenza viruses.
© 2018 Blackwell Verlag GmbH.
KEYWORDS: H3N2 canine influenza virus; evolution; virus host-adaptation
PMID: 30520554 DOI: 10.1111/tbed.13093 [Indexed for MEDLINE]
Keywords: Avian Influenza; Canine Avian Influenza; H3N2; Dogs.