[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]
Volume 25, Number 5—May 2019 / CME ACTIVITY – Research
Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008–2015
Louise Thorlacius-Ussing , Haakon Sandholdt, Anders Rhod Larsen, Andreas Petersen, and Thomas Benfield
Author affiliations: Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark (L. Thorlacius-Ussing, H. Sandholdt, T. Benfield); Statens Serum Institut, Copenhagen (A. Larsen, A. Petersen)
Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008–2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observed for persons >80 years of age: a 90% increase in the SAB rate (p<0.001). After adjusting for demographic changes, annual rates increased 4.0% (95% CI 3.0–5.0) for persons <80 years of age, 8.4% (95% CI 7.0–11.0) for persons 80–89 years of age, and 13.0% (95% CI 9.0–17.5) for persons >90 years of age. The 30-day case-fatality rate remained stable at 24%; crude population death rates increased by 53% during 2008–2015 (p<0.001). Specific causes and mechanisms for this rapid increase in SAB incidence among the elderly population remain to be clarified.
Keywords: Staphylococcus aureus; Bacteremia; Denmark.