#Zika virus #infection among symptomatic patients from two healthcare centers in #SaoPaulo State, #Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics (Rev Inst Med Trop Sao Paulo, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Rev Inst Med Trop Sao Paulo. 2019;61:e19. doi: 10.1590/S1678-9946201961019. Epub 2019 Apr 4.

Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics.

Tozetto-Mendoza TR1, Avelino-Silva VI2, Fonseca S3, Claro IM2, Paula AV1, Levin AS1,2, Sabino EC1,2, Mendes-Correa MC1,2, Figueiredo WM4, Felix AC1, Souza NCS1, Costa AA4, Inenami M4, Silva RMGD4, Levi JE1, Romano CM1, Paranhos-Baccalà G1,5, Segurado AC1,2, Mayaud P1,6.

Author information: 1 Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil. 2 Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil. 3 Hospital São Francisco, Ribeirão Preto, São Paulo, Brazil. 4 Universidade de São Paulo, Faculdade de Saúde Pública, Serviço Especial de Saúde de Araraquara, Araraquara, São Paulo, Brazil. 5 Medical Diagnostic Discovery Department (MD3), bioMérieux SA, Marcy l’Etoile, France. 6 London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom.



Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest <14 days after the symptoms onset (86%), decreasing >28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance.

PMID: 30970110 DOI: 10.1590/S1678-9946201961019

Keywords: Zika Virus; Brazil; Seroprevalence.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.