[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
BMC Public Health. 2018 May 2;18(1):574. doi: 10.1186/s12889-018-5484-8.
MERS transmission and risk factors: a systematic review.
Park JE1, Jung S2, Kim A2, Park JE3,4.
Author information: 1 Research Center for Korean Medicine Policy, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. 2 Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. 3 Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. firstname.lastname@example.org. 4 Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. email@example.com.
Since Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and associated risk factors of MERS.
We searched international (PubMed, ScienceDirect, Cochrane) and Korean databases (DBpia, KISS) for English- or Korean-language articles using the terms “MERS” and “Middle East respiratory syndrome”. Only human studies with > 20 participants were analysed to exclude studies with low representation. Epidemiologic studies with information on transmissibility and severity of MERS as well as studies containing MERS risk factors were included.
A total of 59 studies were included. Most studies from Saudi Arabia reported higher mortality (22-69.2%) than those from South Korea (20.4%). While the R0 value in Saudi Arabia was < 1 in all but one study, in South Korea, the R0 value was 2.5-8.09 in the early stage and decreased to < 1 in the later stage. The incubation period was 4.5-5.2 days in Saudi Arabia and 6-7.8 days in South Korea. Duration from onset was 4-10 days to confirmation, 2.9-5.3 days to hospitalization, 11-17 days to death, and 14-20 days to discharge. Older age and concomitant disease were the most common factors related to MERS infection, severity, and mortality.
The transmissibility and severity of MERS differed by outbreak region and patient characteristics. Further studies assessing the risk of MERS should consider these factors.
KEYWORDS: Infectivity; MERS; Middle East respiratory syndrome; Mortality; Severity
PMID: 29716568 PMCID: PMC5930778 DOI: 10.1186/s12889-018-5484-8 [Indexed for MEDLINE] Free PMC Article