Severe #bornavirus #encephalitis presenting as #GBS (Acta Neuropathol., summary)

[Source: Acta Neuropathologica, full page: (LINK). Summary, edited.]

Severe bornavirus-encephalitis presenting as Guillain–Barré-syndrome

Authors: Roland Coras, Klaus Korn, Stefanie Kuerten, Hagen B. Huttner, Armin Ensser

Correspondence / First Online: 05 April 2019

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The underlying cause of encephalitis and other inflammatory diseases of the human central nervous system remains unclear in a substantial number of cases. Not infrequently, these cases are then assigned an “autoimmune” or “probably infectious” etiology. Two species of bornaviruses are currently unequivocally associated with encephalitis in mammals including humans. Mammalian 2 orthobornavirus (variegated squirrel bornavirus, VSBV) was identified as the cause of encephalitis in breeders of imported squirrels [2]; Mammalian 1 orthobornavirus (BoDV-1 and -2) is the agent of zoonotic borna disease, an encephalitic disease characterized by disturbances of behavior and movements in warm-blooded animals [4] that is most often diagnosed in horses and sheep. Recently, we detected BoDV-1 as the cause of fatal encephalitis in a previously healthy young man [3], and it was found in a cluster of encephalitic disease in organ recipients that received organs of a single donor from southern Bavaria [6…

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Electronic supplementary material

The online version of this article ( https://doi.org/10.1007/s00401-019-02005-z) contains supplementary material, which is available to authorized users.

 

Notes

Acknowledgements

We like to thank Dr. Sybille M. Herzog, Gießen, Germany, for providing the Bo18 antibody and Doris Jungnickl, Brigitte Scholz, and Andrea Hilpert for excellent technical assistance. Research was done with internal funds, and in part by programme overhead financing related to Deutsche Forschungsgemeinschaft Grant EN423/5-1 to Dr. Ensser.

 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Keywords: Orthobornavirus; Variegated Squirrel Bornavirus; Zoonoses; Encephalitis; GBS.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.