#Enzymatic anti- #CRISPRs improve the #bacteriophage #arsenal (Nat Struct Mol Biol., abstract)

[Source: Nature Structural & Molecular Biology, full page: (LINK). Abstract, edited.]

News & Views | Published: 01 April 2019 | CRISPR

Enzymatic anti-CRISPRs improve the bacteriophage arsenal

Shravanti K. Suresh, Karthik Murugan & Dipali G. Sashital

Nature Structural & Molecular Biology (2019)


Bacteriophage-encoded anti-CRISPR (Acr) proteins were previously thought to inhibit CRISPR-mediated immunity by acting as physical barriers against the binding or cleavage of DNA. Two new studies report that recently discovered type V Acr proteins use enzymatic activities to shut down the Cas12a endonuclease, providing a multi-turnover ‘off switch’ for CRISPR-based immunity and technology.


Keywords: CRISPR; Biology; Bacteriophages.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.