[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
Emi Takashita1, Chiharu Kawakami2, Rie Ogawa1, Hiroko Morita1, Seiichiro Fujisaki1, Masayuki Shirakura1, Hideka Miura1, Kazuya Nakamura1, Noriko Kishida1, Tomoko Kuwahara1, Akira Ota3, Hayato Togashi3, Ayako Saito4, Keiko Mitamura5, Takashi Abe6, Masataka Ichikawa7, Masahiko Yamazaki8, Shinji Watanabe1, Takato Odagiri1
Affiliations: 1 Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan; 2 Yokohama City Institute of Public Health, Kanagawa, Japan; 3 Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan; 4 Saito Children’s Clinic, Kanagawa, Japan; 5 Eiju General Hospital, Tokyo, Japan; 6 Abe Children’s Clinic, Kanagawa, Japan; 7 Ichikawa Children’s Clinic, Kanagawa, Japan; 8 Zama Children’s Clinic, Kanagawa, Japan
Correspondence: Takato Odagiritodagirinih.go.jp
Citation style for this article: Takashita Emi, Kawakami Chiharu, Ogawa Rie, Morita Hiroko, Fujisaki Seiichiro, Shirakura Masayuki, Miura Hideka, Nakamura Kazuya, Kishida Noriko, Kuwahara Tomoko, Ota Akira, Togashi Hayato, Saito Ayako, Mitamura Keiko, Abe Takashi, Ichikawa Masataka, Yamazaki Masahiko, Watanabe Shinji, Odagiri Takato. Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. Euro Surveill. 2019;24(12):pii=1900170. https://doi.org/10.2807/1560-7917.ES.2019.24.12.1900170
Received: 06 Mar 2019; Accepted: 21 Mar 2019
In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans.
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Keywords: Antivirals; Drugs Resistance; Baloxavir; Seasonal Influenza; H3N2; Japan.