[Source: Cell Host & Microbe, full page: (LINK). Summary, edited.]
Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?
Priyadharshini Devarajan, Susan L. Swain
In this issue of Cell Host & Microbe, two articles ( Lee et al., 2019, Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.
Keywords: Influenza A; Vaccines; Original Antigenic Sin.