Reduced Susceptibility to #Neuraminidase #Inhibitors in #Influenza B Isolate, #Canada (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 25, Number 4—April 2019 / Research Letter

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Yacine Abed1, Clément Fage1, Patrick Lagüe, Julie Carbonneau, Jesse Papenburg, Donald C. Vinh, and Guy Boivin

Author affiliations: Laval University, Québec City, Québec, Canada (Y. Abed, C. Fage, P. Lagüe, J. Carbonneau, G. Boivin); Montreal Children’s Hospital, Montreal, Québec (J. Papenburg); McGill University Health Center, Montreal (D.C. Vinh)

 

Abstract

We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374 residue. The potential emergence of such variants emphasizes the need for new antivirals.

Keywords: Seasonal Influenza; Influenza B; Antivirals; Drugs Resistance; Oseltamivir; Zanamivir; Peramivir; Canada.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.