[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]
Successful treatment of Pseudomonas aeruginosainfective endocarditis via haemodialysis outpatient parenteral antimicrobial therapy: case report
Hector Maxwell-Scott, Rajeni Thangarajah, Amber Arnold, Paul Wade, John L Klein
Journal of Antimicrobial Chemotherapy, dkz096, https://doi.org/10.1093/jac/dkz096
Published: 04 March 2019
Pseudomonas aeruginosa infective endocarditis (IE) is rare and difficult to treat, often requiring long hospital admissions for intravenous antibiotics. Outpatient parenteral antimicrobial therapy (OPAT) is one option for the management of infection allowing for shorter inpatient stays. Certain antibiotics can be dosed for administration on haemodialysis, allowing for haemodialysis OPAT (HD-OPAT), but less is known about their pharmacokinetics and pharmacodynamics in this setting. Here we present a case of P. aeruginosa IE successfully treated with HD-OPAT using ceftazidime and oral ciprofloxacin.
Keywords: Antibiotics; Pseudomonas aeruginosa; Endocarditis; Ceftazidime; Azithromycin.