[Source: Nature Communications, full page: (LINK). Abstract, edited.]
Article | OPEN | Published: 26 February 2019
Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika
Paulina Andrade, Ciara Gimblet-Ochieng, Faraz Modirian, Matthew Collins, Maritza Cárdenas, Leah C. Katzelnick, Magelda Montoya, Daniela Michlmayr, Guillermina Kuan, Angel Balmaseda, Josefina Coloma, Aravinda M. de Silva & Eva Harris
Nature Communications, volume 10, Article number: 938 (2019)
Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.
Keywords: Dengue fever; Zika Virus; Immunology.