Potential Intermediate #Hosts for #Coronavirus Transmission: No Evidence of Clade 2c Coronaviruses in Domestic #Livestock from #Ghana (Trop Med Infect Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Trop Med Infect Dis. 2019 Feb 10;4(1). pii: E34. doi: 10.3390/tropicalmed4010034.

Potential Intermediate Hosts for Coronavirus Transmission: No Evidence of Clade 2c Coronaviruses in Domestic Livestock from Ghana.

El-Duah P1,2, Sylverken A3,4, Owusu M5,6, Yeboah R7,8, Lamptey J9,10, Frimpong YO11,12, Burimuah V13,14, Antwi C15, Folitse R16, Agbenyega O17, Oppong S18, Adu-Sarkodie Y19.

Author information: 1 Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. elduahphilip9@gmail.com. 2 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. elduahphilip9@gmail.com. 3 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. annan@kccr.de. 4 Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. annan@kccr.de. 5 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. owusumichael-gh@hotmail.com. 6 Department of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. owusumichael-gh@hotmail.com. 7 Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. Yeboahrichmond82@yahoo.com. 8 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. Yeboahrichmond82@yahoo.com. 9 Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. jlamptey80@gmail.com. 10 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. jlamptey80@gmail.com. 11 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. oppongfrimpong1@gmail.com. 12 Department of Animal Science, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. oppongfrimpong1@gmail.com. 13 Kumasi Centre for Collaborative Research in Tropical Medicine, PMB, UPO, Kumasi 00233, Ghana. vitus7uk@yahoo.co.uk. 14 School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. vitus7uk@yahoo.co.uk. 15 Department of Animal Science, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. cantwi@icloud.com. 16 School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. raphfolitse@yahoo.com. 17 Department of Agroforestry, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. olivia_agbenyega@yahoo.com. 18 Department of Wildlife and Range Management, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. kobbyoppong@yahoo.com. 19 Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana. yasax@hotmail.co.uk.

 

Abstract

The emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade ago with worldwide distribution, was believed to be of zoonotic origin from bats with dromedary camels as intermediate hosts. There is a likelihood of other domestic livestock serving as intermediate hosts for this virus. The presence of coronaviruses, closely related to MERS-CoV in Ghanaian bats, presented the opportunity to test the hypothesis of transmissibility of this virus through domestic livestock species. The possible interactions between livestock and bats in 31 household farms were accessed by observation and interviews with farmers. Rectal swabs and serum from cattle, sheep, goats, donkeys, and swine from commercial and household farms were tested for MERS-CoV and a Nycteris sp. bat coronavirus, previously detected in Ghana. A pan-PCR assay to detect clade 2c viruses and recombinant immunofluorescence assay to detect anti-spike IgG antibodies against the target viruses were used. Likely contact between livestock and bats was determined for 13 farms (41.9%) that reported confining their livestock and also observing bats in their homes. Livestock were left unconfined on eight farms (25.8%) that also observed bats roosting in trees close to their homes. No viral RNA or antibodies against the two coronaviruses were detected in any of the livestock species tested. Cattle, sheep, goats, donkeys, and swine are not likely hosts of clade 2c coronaviruses.

KEYWORDS: bats; coronavirus; intermediate host; livestock

PMID: 30744201 DOI: 10.3390/tropicalmed4010034 Free full text

Keywords: Coronavirus; MERS-CoV; Bats; Cattle; Pigs; Ghana.

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Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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