[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Clin Exp Vaccine Res. 2019 Jan;8(1):86-88. doi: 10.7774/cevr.2019.8.1.86. Epub 2019 Jan 31.
Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.
Choi JY1,2, Oh JO1, Ahn JY3, Choi H1, Kim JH1, Seong H1, Jeong SJ1,2, Ku NS1,2, Yeom JS1, Choi JP3.
Author information: 1 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. 2 AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. 3 Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
KEYWORDS: Middle East respiratory syndrome coronavirus; Neutralizing antibodies; Serum
PMID: 30775355 PMCID: PMC6369131 DOI: 10.7774/cevr.2019.8.1.86
Keywords: MERS-CoV; Serology; Antivirals; S. Korea.