Absence of neutralizing #activity in #serum 1 year after successful #treatment with #antivirals and recovery from #MERS in South #Korea (Cli Exp Vaccine Res., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Clin Exp Vaccine Res. 2019 Jan;8(1):86-88. doi: 10.7774/cevr.2019.8.1.86. Epub 2019 Jan 31.

Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.

Choi JY1,2, Oh JO1, Ahn JY3, Choi H1, Kim JH1, Seong H1, Jeong SJ1,2, Ku NS1,2, Yeom JS1, Choi JP3.

Author information: 1 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. 2 AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. 3 Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.

 

Abstract

We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.

KEYWORDS: Middle East respiratory syndrome coronavirus; Neutralizing antibodies; Serum

PMID: 30775355 PMCID: PMC6369131 DOI: 10.7774/cevr.2019.8.1.86

Keywords: MERS-CoV; Serology; Antivirals; S. Korea.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.