#Antibody Determinants of #Influenza #Immunity (J Infect Dis., abstract)

[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]

Antibody Determinants of Influenza Immunity

James E Crowe, Jr

The Journal of Infectious Diseases, jiz010, https://doi.org/10.1093/infdis/jiz010

Published: 31 January 2019

 

Abstract

Understanding the antigenic variation in circulating influenza virus strains and how the human immune system recognizes diverse virus strains is one of the central challenges of our time for human vaccinologists. Antibodies directed to the two major integral membrane proteins on the surface of viral particles, hemagglutinin (HA) and neuraminidase (NA), mediate protection against reinfection following natural infection or vaccination, but the HA and NA proteins in field strains are highly variable in sequence. The central questions about influenza immunity today are how to achieve protective antibody responses in a higher proportion of individuals, and how to induce responses with more breadth and more durability. Recent studies using isolation of human monoclonal antibodies followed by structural and functional characterization have revealed conserved antigenic sites that are recognized by broadly cross-reactive antibodies. The antigenic landscape on the HA and NA proteins is coming into focus in a way that informs new studies of the correlates and mechanisms of immunity. Understanding the antibody determinants of influenza immunity points the way toward development and testing of next generation vaccines that have the potential to confer broadly protective immunity.

Orthomyxoviridae Infections, Influenza A virus, Antibodies, Viral, Antibodies, Neutralizing, Hemagglutination Inhibition Tests, Antibody-Dependent Cell Cytotoxicity

Topic: influenza – immunity – antibodies

Issue Section: Supplement Article

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Keywords: Influenza A; Immunology.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.