#H2 #influenza viruses: designing #vaccines against future H2 #pandemics (Biochem Soc Trans., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Biochem Soc Trans. 2019 Jan 15. pii: BST20180602. doi: 10.1042/BST20180602. [Epub ahead of print]

H2 influenza viruses: designing vaccines against future H2 pandemics.

Reneer ZB1, Ross TM2,3.

Author information: 1 Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A. 2 Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A. tedross@uga.edu. 3 Department of Infectious Diseases, University of Georgia, Athens, GA 30602, U.S.A.



Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 ‘Asian Flu’ pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world’s population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

KEYWORDS: H2N2; influenza; pandemic; vaccine; virus

PMID: 30647144 DOI: 10.1042/BST20180602

Keywords: Pandemic Influenza; H2N2; Avian Influenza; Vaccines.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.