#Seroprevalence of #Dengue and #Zika Virus in #Blood #Donations: A Systematic Review (Transfus Med Rev., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Transfus Med Rev. 2018 Oct 31. pii: S0887-7963(18)30094-4. doi: 10.1016/j.tmrv.2018.10.001. [Epub ahead of print]

Seroprevalence of Dengue and Zika Virus in Blood Donations: A Systematic Review.

Eick SM1, Dale AP2, McKay B3, Lawrence C4, Ebell MH5, Cordero JF6, Welton M7.

Author information: 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: eick.steph@gmail.com. 2 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: aperrydale@gmail.com. 3 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: bmckay81@gmail.com. 4 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: crl99301@uga.edu. 5 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: ebell@uga.edu. 6 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: jcordero@uga.edu. 7 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA. Electronic address: Michael.welton@gmail.com.

 

Abstract

The presence of antibodies to Zika virus (ZIKV) and dengue virus (DENV) can be detected in blood donations. Donation-based surveillance provides an alternative strategy to estimate population prevalence by detecting antibodies that are circulating. To estimate population prevalence, we conducted a systematic review of literature on the seroprevalence of ZIKV and DENV antibodies in blood donations. We searched PubMed and Web of Science for studies that reported the seroprevalence of ZIKV and DENV in blood donations. The title and abstract of each study were screened by 2 reviewers simultaneously for possible inclusion, and the full text of selected studies was reviewed to ensure that they met inclusion criteria (used primary data collection, reported evidence of immunoglobulin M (IgM) or immunoglobulin G (IgG) antibodies in the blood supply, and included a representative sample of the total population). Immunoglobin test measuring levels of antibodies to IgM and IgG and number of positive cases were extracted from each study. No exclusions were made based on language or country. Our initial search identified 1890 studies after excluding duplicates, of which 76 were assessed for full text eligibility to ensure that they met our final inclusion criteria. There were 14 studies included in our review; 11 examined the seroprevalence of DENV, and 3 examined ZIKV. The highest seroprevalence by IgM was 2.82% for DENV and 0.53% for ZIKV. Our results indicate that the seroprevalence of ZIKV and DENV antibody presence in countries with active transmission is higher than reports by traditional surveillance in some countries. This finding is expected due to the large percentage of asymptomatic cases. The highest seroprevalence was observed for IgG, which can persist over long periods of time compared to IgM. Screening of blood donations may help supplement traditional surveillance measures, especially during outbreak settings.

KEYWORDS: Blood donations; Blood supply; Dengue virus; Surveillance; Transmission; Zika virus

PMID: 30471867 DOI: 10.1016/j.tmrv.2018.10.001

Keywords: Zika Virus; Dengue Fever; Blood Safety; Seroprevalence.

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gimi69

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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