#Prevalence of #comorbidities in cases of #MERS #coronavirus: a retrospective study (Epidemiol Infect., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Epidemiol Infect. 2018 Nov 5:1-5. doi: 10.1017/S0950268818002923. [Epub ahead of print]

Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study.

Alqahtani FY1, Aleanizy FS1, Ali El Hadi Mohamed R2, Alanazi MS3, Mohamed N4, Alrasheed MM5, Abanmy N5, Alhawassi T5.

Author information: 1 Department of Pharmaceutics,College of Pharmacy, King Saud University,22452 Riyadh 11495,Saudi Arabia. 2 College of Science, Princess Nourah Bint Abdulrahman University,Riyadh 12484,Saudi Arabia. 3 Emergency medicine consultant,Emergency Department,Prince Mohamed Bin Abdulaziz Hospital,Ministry of Health,Riyadh 12455,Saudi Arabia. 4 College of Medicine, Princess Nourah bint Abdulrahman University,Riyadh 12484,Saudi Arabia. 5 Department of Clinical Pharmacy,College of Pharmacy, King Saud University,22452 Riyadh 11495,Saudi Arabia.



The Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening respiratory disease with a high case fatality rate; however, its risk factors remain unclear. We aimed to explore the influence of demographic factors, clinical manifestations and underlying comorbidities on mortality in MERS-CoV patients. Retrospective chart reviews were performed to identify all laboratory-confirmed cases of MERS-COV infection in Saudi Arabia that were reported to the Ministry of Health of Saudi Arabia between 23 April 2014 and 7 June 2016. Statistical analyses were conducted to assess the effect of sex, age, clinical presentation and comorbidities on mortality from MERS-CoV. A total of 281 confirmed MERS-CoV cases were identified: 167 (59.4%) patients were male and 55 (20%) died. Mortality predominantly occurred among Saudi nationals and older patients and was significantly associated with respiratory failure and shortness of breath. Of the 281 confirmed cases, 160 (56.9%) involved comorbidities, wherein diabetes mellitus, hypertension, ischemic heart disease, congestive heart failure, end-stage renal disease and chronic kidney disease were significantly associated with mortality from MERS-CoV and two or three comorbidities significantly affected the fatality rates from MERS-CoV. The findings of this study show that old age and the existence of underlying comorbidities significantly increase mortality from MERS-CoV.

KEYWORDS: Comorbidities; middle east respiratory syndrome coronavirus; mortality

PMID: 30394248 DOI: 10.1017/S0950268818002923

Keywords: MERS-CoV.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.