Mechanisms of high-level #ceftolozane/tazobactam #resistance in #Pseudomonas aeruginosa from a severely #neutropenic patient and treatment success from synergy with #tobramycin (J Antimicrob Chemother., abstract)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]

Mechanisms of high-level ceftolozane/tazobactam resistance in Pseudomonas aeruginosa from a severely neutropenic patient and treatment success from synergy with tobramycin

Wonhee So, James Shurko, Ralph Galega, Rod Quilitz, John N Greene, Grace C Lee

Journal of Antimicrobial Chemotherapy, dky393,

Published: 08 October 2018



We read the article by Fraile-Ribot et al.1 with great interest and herein report another case of ceftolozane/tazobactam-resistant Pseudomonas aeruginosabacteraemia that developed after 5 weeks of exposure to ceftolozane/tazobactam. A retrospective review of the medical records of a single patient case does not mandate review by the University of South Florida College of Medicine Institutional Review Board (IRB), thus informed consent was not required.

… The patient had AML and was induced with cladribine, cytarabine, filgrastim plus mitoxantrone on days 1–6 then reinduced with 5 days of cladribine plus cytarabine on days 15–19. The patient had a long history of hidradenitis…


Topic: pseudomonas aeruginosa – neutropenia – tobramycin – tazobactam – ceftolozane

Issue Section: Research letter

© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email:

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (

Keywords: Antibiotics; Drugs Resistance; Pseudomonas aeruginosa; Ceftolozane; Tazobactam; Tobramycin.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum ( in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.