[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
Obesity Increases the Duration of Influenza A Virus Shedding in Adults
Hannah E Maier, Roger Lopez, Nery Sanchez, Sophia Ng, Lionel Gresh, Sergio Ojeda, Raquel Burger-Calderon, Guillermina Kuan, Eva Harris, Angel Balmaseda, Aubree Gordon
The Journal of Infectious Diseases, jiy370, https://doi.org/10.1093/infdis/jiy370
Published: 02 August 2018
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015–2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06–1.89); no association was observed with influenza B virus shedding duration. Even among paucisymptomatic and asymptomatic adults, obesity increased the influenza A shedding duration by 104% (adjusted ETR, 2.04; 95% CI, 1.35–3.09). These findings suggest that obesity may play an important role in influenza transmission.
Influenza virus, obesity, viral shedding, paucisymptomatic, asymptomatic, transmission, household, epidemiology, public health
Topic: obesity – influenza – adult – influenza a virus – nicaragua – orthomyxoviridae – virus shedding
Issue Section: Brief Report
Keywords: Influenza A; Seasonal Influenza; Obesity; Nicaragua.