Postexposure Efficacy of Recombinant #VSV Vectors Against High and Low Doses of #Marburg Virus Variant Angola in Nonhuman Primates (J Infect Disl, abstract)

[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Courtney Woolsey, Joan B Geisbert, Demetrius Matassov, Krystle N Agans, Viktoriya Borisevich, Robert W Cross, Daniel J Deer, Karla A Fenton, John H Eldridge, Chad E Mire, Thomas W Geisbert

The Journal of Infectious Diseases, jiy293, https://doi.org/10.1093/infdis/jiy293

Published: 25 June 2018

 

Abstract

A recombinant vesicular stomatitis virus (rVSV) expressing the Marburg virus (MARV) Musoke variant glycoprotein fully protects macaques against 2 MARV variants and Ravn virus as a preventive vaccine and MARV variant Musoke as a postexposure treatment. To evaluate postexposure efficacy against the most pathogenic MARV variant, Angola, we engineered rVSVs expressing homologous Angola glycoprotein. Macaques were challenged with high or low doses of variant Angola and treated 20–30 minutes after exposure. A total of 25% and 60%–75% of treated macaques survived the high-dose and low-dose challenges, respectively. The more rapid disease progression of variant Angola versus variant Musoke may account for the incomplete protection observed.

Marburg virus, Angola, Musoke, filovirus, recombinant vesicular stomatitis virus, vaccine, treatment

Issue Section: Supplement Article

Keywords: Marburg Virus; Ravn Virus; Vaccines; Animal Models.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.