[Source: US National Library of Medicine, full page: (LINK). Abstract , edited.]
J Acquir Immune Defic Syndr. 2018 Apr 27. doi: 10.1097/QAI.0000000000001718. [Epub ahead of print]
Zika Virus Exposure in an HIV-Infected Cohort in Ghana.
Sherman KE1, Rouster SD1, Kong LX1, Shata TM1, Archampong T2, Kwara A3, Aliota MT4, Blackard JT1.
Author information: 1 University of Cincinnati College of Medicine, Cincinnati, OH, USA. 2 University of Ghana School of Medicine and Dentistry, College of Health Sciences, Accra, Ghana. 3 Warren Alpert Medical School of Brown University, Providence, RI, USA. 4 University of Wisconsin- Madison, WI.
To determine the prevalence and epidemiologic associations of Zika Virus (ZIKV) in HIV-infected patients in Ghana, West Africa.
We examined the seroprevalence of ZIKV in HIV/HBV co-infected persons in Ghana from sera samples collected from 2012 to 2014 using ELISA assays and plaque reduction neutralization tests (PRNT).
Overall, ZIKV antibody was detected in 12.9% of 236 tested samples, though the true estimate of exposure is probably less due cross-reactions with other related viruses. PRNTs were performed on a subset to provide an estimate of the frequency of false positive reaction. Dengue virus testing was also performed and antibody prevalence was 87.2%. The median CD4 count was 436 (range 2-1781 cell/mm) and did not affect antibody results. Regional geographic ethnicity was associated with ZIKV exposure.
Overall, these data suggest that ZIKV infection is a relatively prevalent infection in HIV-positive persons in Ghana though not as common as dengue. Further evaluation of the effect of ZIKV and HIV co-infection is warranted given the large geographical overlap of populations exposed to both viruses.
PMID: 29771784 DOI: 10.1097/QAI.0000000000001718
Keywords: Zika Virus; HIV/AIDS; Ghana.