#Zika Virus #Exposure in an #HIV-Infected Cohort in #Ghana (J Acquir Immune Defic Syndr., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract , edited.]

J Acquir Immune Defic Syndr. 2018 Apr 27. doi: 10.1097/QAI.0000000000001718. [Epub ahead of print]

Zika Virus Exposure in an HIV-Infected Cohort in Ghana.

Sherman KE1, Rouster SD1, Kong LX1, Shata TM1, Archampong T2, Kwara A3, Aliota MT4, Blackard JT1.

Author information: 1 University of Cincinnati College of Medicine, Cincinnati, OH, USA. 2 University of Ghana School of Medicine and Dentistry, College of Health Sciences, Accra, Ghana. 3 Warren Alpert Medical School of Brown University, Providence, RI, USA. 4 University of Wisconsin- Madison, WI.

 

Abstract

OBJECTIVE:

To determine the prevalence and epidemiologic associations of Zika Virus (ZIKV) in HIV-infected patients in Ghana, West Africa.

METHODS:

We examined the seroprevalence of ZIKV in HIV/HBV co-infected persons in Ghana from sera samples collected from 2012 to 2014 using ELISA assays and plaque reduction neutralization tests (PRNT).

RESULTS:

Overall, ZIKV antibody was detected in 12.9% of 236 tested samples, though the true estimate of exposure is probably less due cross-reactions with other related viruses. PRNTs were performed on a subset to provide an estimate of the frequency of false positive reaction. Dengue virus testing was also performed and antibody prevalence was 87.2%. The median CD4 count was 436 (range 2-1781 cell/mm) and did not affect antibody results. Regional geographic ethnicity was associated with ZIKV exposure.

DISCUSSION:

Overall, these data suggest that ZIKV infection is a relatively prevalent infection in HIV-positive persons in Ghana though not as common as dengue. Further evaluation of the effect of ZIKV and HIV co-infection is warranted given the large geographical overlap of populations exposed to both viruses.

PMID: 29771784 DOI: 10.1097/QAI.0000000000001718

Keywords: Zika Virus; HIV/AIDS; Ghana.

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Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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