[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Gen Virol. 2018 May 17. doi: 10.1099/jgv.0.001080. [Epub ahead of print]
An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.
Delatorre E1, Miranda M2,3,4, Tschoeke DA5,2,3, Carvalho de Sequeira P6, Alves Sampaio S6, Barbosa-Lima G7,8,9, Rangel Vieira Y7,8,9, Leomil L2,3, Bozza FA8,9, Cerbino-Neto J9, Bozza PT8, Ribeiro Nogueira RM6, Brasil P9, Thompson FL2,3, de Filippis AMB6, Souza TML7,9,8.
Author information: 1 1Laboratório de AIDS and Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil. 2 4SAGE -COPPE, UFRJ, Rio de Janeiro, RJ, Brazil. 3 3Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. 4 2Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. 5 5Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, Brazil. 6 6Laboratório de Flavivírus, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. 7 9National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil. 8 8Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil. 9 7Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil.
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).
PMID: 29771234 DOI: 10.1099/jgv.0.001080
Keywords: Zika Virus; Neuroinvasion.