An observational #clinical case of #Zika virus-associated #neurological disease is associated with primary #IgG response and enhanced TNF levels (J Gen Virol., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

J Gen Virol. 2018 May 17. doi: 10.1099/jgv.0.001080. [Epub ahead of print]

An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.

Delatorre E1, Miranda M2,3,4, Tschoeke DA5,2,3, Carvalho de Sequeira P6, Alves Sampaio S6, Barbosa-Lima G7,8,9, Rangel Vieira Y7,8,9, Leomil L2,3, Bozza FA8,9, Cerbino-Neto J9, Bozza PT8, Ribeiro Nogueira RM6, Brasil P9, Thompson FL2,3, de Filippis AMB6, Souza TML7,9,8.

Author information: 1 1​Laboratório de AIDS and Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil. 2 4​SAGE -COPPE, UFRJ, Rio de Janeiro, RJ, Brazil. 3 3​Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. 4 2​Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. 5 5​Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, Brazil. 6 6​Laboratório de Flavivírus, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. 7 9​National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil. 8 8​Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil. 9 7​Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil.



Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).

PMID: 29771234 DOI: 10.1099/jgv.0.001080

Keywords: Zika Virus; Neuroinvasion.


Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum ( in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.