[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
Longitudinal study of cellular and systemic cytokines signatures define the dynamics of a balanced immune environment in disease manifestation in Zika virus-infected patients
Fok-Moon Lum, David C B Lye, Jeslin J L Tan, Bernett Lee, Po-Ying Chia, Tze-Kwang Chua, Siti N Amrun, Yiu-Wing Kam, Wearn-Xin Yee, Wei-Ping Ling, Vanessa W X Lim, Vincent J X Pang, Linda K Lee, Esther W H Mok, Chia-Yin Chong, Yee-Sin Leo, Lisa F P Ng
The Journal of Infectious Diseases, jiy225, https://doi.org/10.1093/infdis/jiy225
Published: 16 April 2018
The unexpected re-emergence of Zika virus (ZIKV) has caused numerous outbreaks globally. This study characterized the host immune responses during ZIKV infection.
Patient samples were collected longitudinally during the acute, convalescence and recovery phases of ZIKV infection over 6 months during the Singapore outbreak in late 2016. Plasma immune mediators were profiled via multiplex micro-bead assay, while changes in blood cell numbers were determined with immune-phenotyping.
Data showed the involvement of various immune mediators during acute ZIKV infection accompanied by a general reduction in blood cell numbers for all immune subsets except CD14+ monocytes. Importantly, viremic patients experiencing moderate symptoms had significantly higher quantities of IP-10, MCP-1, IL-1RA, IL-8 and PIGF-1, accompanied by reduced numbers of peripheral CD8+, CD4+ and DNT cells. Levels of T-cell associated mediators including IP-10, IFNγ, and IL-10 were high in recovery phases of ZIKV infection, suggesting a functional role for T-cells. The identification of different markers at specific disease phases emphasizes the dynamics of a balanced cytokine environment in disease progression.
This is the first comprehensive study that highlights specific cellular changes and immune signatures during ZIKV disease progression and provides valuable insights into ZIKV immuno-pathogenesis.
Topic: cytokine – biological response modifiers – blood cell count – disease outbreaks – disease progression – t-lymphocyte – viruses – immune mediator – phenotype determination – zika virus – zika virus disease
Issue Section: Major Article
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Zika Virus; Immunopathogenesis.