#Mosquito #saliva re-shapes #alphavirus #infection and immunopathogenesis (J Virol., abstract)

[Source: Journal of Virology, full page: (LINK). Abstract, edited.]

Mosquito saliva re-shapes alphavirus infection and immunopathogenesis

Siew-Wai Fong a,b, R. Manjunatha Kini a and Lisa F.P. Ng b,c#

Author Affiliations: a Department of Biological Science, National University of Singapore, Singapore 117543, Singapore; b Singapore Immunology Network, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore 138648, Singapore; c Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, United Kingdom

 

ABSTRACT

Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide magnitude of outbreaks and crippling disease, licensed vaccines or antiviral therapies remain limited. Mosquito vectors such as Aedes and Culex are the main culprits in the transmission of alphaviruses. This review explores how mosquito saliva may promote alphavirus infection. Identifying the roles of mosquito-derived factors in alphavirus pathogenesis will generate novel tools to circumvent and control mosquito-borne alphavirus infections in humans.

 

FOOTNOTES

#Address correspondence to Lisa F.P.Ng, lisa_ng@immunol.a-star.edu.sg

Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Keywords: Alphavirus; Mosquitoes; Culex spp.; Aedes spp.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.