[Source: Journal of Virology, full page: (LINK). Abstract, edited.]
Mosquito saliva re-shapes alphavirus infection and immunopathogenesis
Siew-Wai Fong a,b, R. Manjunatha Kini a and Lisa F.P. Ng b,c#
Author Affiliations: a Department of Biological Science, National University of Singapore, Singapore 117543, Singapore; b Singapore Immunology Network, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore 138648, Singapore; c Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, United Kingdom
Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide magnitude of outbreaks and crippling disease, licensed vaccines or antiviral therapies remain limited. Mosquito vectors such as Aedes and Culex are the main culprits in the transmission of alphaviruses. This review explores how mosquito saliva may promote alphavirus infection. Identifying the roles of mosquito-derived factors in alphavirus pathogenesis will generate novel tools to circumvent and control mosquito-borne alphavirus infections in humans.
#Address correspondence to Lisa F.P.Ng, firstname.lastname@example.org
Copyright © 2018 American Society for Microbiology. All Rights Reserved.
Keywords: Alphavirus; Mosquitoes; Culex spp.; Aedes spp.