Clinical #outcomes after combination #treatment with #ceftazidime / #avibactam and #aztreonam for NDM-1/OXA-48/CTX-M-15-producing #Klebsiella pneumoniae infection (J Antimicrob Chemother., summary)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Summary, edited.]

Clinical outcomes after combination treatment with ceftazidime/avibactam and aztreonam for NDM-1/OXA-48/CTX-M-15-producing Klebsiella pneumoniae infection

Evelyn Shaw, Alexander Rombauts, Fe Tubau, Ariadna Padullés, Jordi Càmara, Toni Lozano, Sara Cobo-Sacristán, Núria Sabe, Imma Grau, Raül Rigo-Bonnin, M Angeles Dominguez, Jordi Carratalà

Journal of Antimicrobial Chemotherapy, dkx496,

Published:  19 December 2017



The growing spread of bacteria producing carbapenemases, such as the New Delhi MBL (NDM),1 has created an urgent need to identify effective therapeutic options that can treat serious infections caused by these XDR bacteria. Ceftazidime/avibactam has been successfully used to treat infection caused by carbapenem-resistant Enterobacteriaceae;2,3 however, the combination lacks activity against strains producing NDM. These carbapenemases remain susceptible to aztreonam, although most MBL-producing isolates also harbour ESBLs or other β-lactamases that confer resistance to aztreonam.4 The combination of aztreonam and avibactam has demonstrated potent in vitroactivity against MBL-producing Enterobacteriaceae including those isolates that also carry other β-lactamases.5 However, this combination is currently in clinical development and unavailable for clinical use.



Issue Section:  Research letter

© The Author(s) 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email:

Keywords: Antibiotics; Drugs Resistance; Klebsiella Pneumoniae; NDM1; Ceftazidime; Avibactam; Aztreonam.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum ( in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.