#Tigecycline as a Second-Line Agent for #Legionnaires’ Disease in Severely Ill Patients (Open Forum Infect Dis., abstract)

[Source: Open Forum Infectious Diseases, full page: (LINK). Abstract, edited.]

Tigecycline as a Second-Line Agent for Legionnaires’ Disease in Severely Ill Patients

Deepika Slawek, Diana Altshuler, Yanina Dubrovskaya, Eddie Louie

Open Forum Infectious Diseases, Volume 4, Issue 4, 1 October 2017, ofx184,  DOI: https://doi.org/10.1093/ofid/ofx184

Published: 07 October 2017 – Received: 18 May 2017 – Accepted: 30 August 2017

Citation: Deepika Slawek, Diana Altshuler, Yanina Dubrovskaya, Eddie Louie; Tigecycline as a Second-Line Agent for Legionnaires’ Disease in Severely Ill Patients, Open Forum Infectious Diseases, Volume 4, Issue 4, 1 October 2017, ofx184, https://doi.org/10.1093/ofid/ofx184

© 2017 Oxford University Press

 

Abstract

Treatment of Legionnaires’ disease in severely ill or immunosuppressed patients presents a clinical challenge. Tigecycline (TG) achieves high concentrations intracellularly and has been shown to be effective against L. pneumophila in animal and cell models. We report our experience using TG as second-line therapy. Clinical response was seen in most patients after switching to TG alone or as a combination therapy.

Issue Section: Brief Report

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Keywords: Tigecycline; Legionellosis.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.