A new variant of #mcr3 in an #XDR #Escherichia coli clinical isolate carrying #mcr1 and #blaNDM-5 (AAC, abstract)

[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]

A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5

Lu Liu1,2,  Yu Feng1,2,  Xiaoxia Zhang1,2,  Alan McNally5 and Zhiyong Zong1,2,3,4*

Author Affiliations: 1 Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. 2 Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China. 3 Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China. 4 Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China. 5 Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.



A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5. mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.



*Corresponding author. Mailing address: Center of Infectious Diseases, West China Hospital (Huaxi), Guoxuexiang 37, Chengdu 610041, China. Phone: 86-28-8542-2637. Fax: 86-28-8542-3212. E-mail: zongzhiy@scu.edu.cn

Copyright © 2017 American Society for Microbiology. All Rights Reserved.

Keywords: Antibiotics; Drugs Resistance; E. Coli; Colistin; Carbapenem; MCR1; MCR3.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.