[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
A new variant of mcr-3 in an extensively drug-resistant Escherichia coli clinical isolate carrying mcr-1 and blaNDM-5
Lu Liu1,2, Yu Feng1,2, Xiaoxia Zhang1,2, Alan McNally5 and Zhiyong Zong1,2,3,4*
Author Affiliations: 1 Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. 2 Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China. 3 Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China. 4 Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China. 5 Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5. mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.
*Corresponding author. Mailing address: Center of Infectious Diseases, West China Hospital (Huaxi), Guoxuexiang 37, Chengdu 610041, China. Phone: 86-28-8542-2637. Fax: 86-28-8542-3212. E-mail: email@example.com
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Keywords: Antibiotics; Drugs Resistance; E. Coli; Colistin; Carbapenem; MCR1; MCR3.