#Evolution and spatio-temporal #dynamics of #Enterovirus A71 subgenogroups in #Vietnam (J Infect Dis., abstract)

[Source: The Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]

Evolution and spatio-temporal dynamics of Enterovirus A71 subgenogroups in Vietnam

Nguyen Thi Thanh, Celeste Donato, Vu Thi Huyen Trang, Nguyen Trung Kien, Phạm Mai Thuy Trang, Tran Quoc Khanh, Dang Thi Nguyet, Hoang Quoc Cuong, Phan Trong Lan, Vu Thi Que Huong, H Rogier van Doorn, Vijaykrishna Dhanasekaran

#Corresponding author: Vijaykrishna Dhanasekaran vijay.dhanasekaran@monash.edu Department of Microbiology 19 Innovation Drive Monash University Clayton 3800 Phone: +613 9905 5415 Fax: +613 9902 9222

The Journal of Infectious Diseases, jix500, https://doi.org/10.1093/infdis/jix500

Published: 23 September 2017 – Received: 28 February 2017

Citation: Nguyen Thi Thanh Thao, Celeste Donato, Vu Thi Huyen Trang, Nguyen Trung Kien, Phạm Mai Thuy Trang, Tran Quoc Khanh, Dang Thi Nguyet, October Sessions, Hoang Quoc Cuong, Phan Trong Lan, Vu Thi Que Huong, H Rogier van Doorn, Vijaykrishna Dhanasekaran; Evolution and spatio-temporal dynamics of Enterovirus A71 subgenogroups in Vietnam, The Journal of Infectious Diseases, , jix500, https://doi.org/10.1093/infdis/jix500

© 2017 Oxford University Press




Enterovirus A71 (EV-A71) is the major cause of severe hand, foot and mouth disease and viral encephalitis in children across the Asia-Pacific region, including in Vietnam which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5 and B5) concurrently circulate in the region with a large variation in epidemic severity. The relative differences in their evolution and epidemiology were examined within Vietnam and globally.


A total of 752 VP1 gene sequences were analysed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003–2013 along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to co-estimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network.


Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specific Asian countries representing genogroup-specific sources of EV-A71 diversity.


This study highlights a persistent transmission network of EV-A71, with specific Asian countries seeding other countries in the region and beyond, emphasising the need for improved EV-A71 surveillance and detailed genetic and antigenic characterisation.

Enterovirus A71, Vietnam, Hand Foot and Mouth Disease, Phylogenetics

Topic: metadata – enterovirus – epidemiology – hand-foot-and-mouth disease – asia – child – cost of illness – viral encephalitis – genes – phylogeny – vietnam – genetics – viruses – persistence – epidemic – surveillance, medical – asian – absolute risk reduction – genbank – datasets

Issue Section: Major Article

© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords: EV-71; HFMD; Asian Region; Vietnam.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.