[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
Eurosurveillance, Volume 22, Issue 31, 03 August 2017 / Rapid communication
Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014
L Roer 1 , F Hansen 1 , M Stegger 1 , UW Sönksen 1 , H Hasman 1 , AM Hammerum 1
Author affiliations: 1. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
Correspondence: Louise Roer (loro@ssi.dk)
Citation style for this article: Roer L, Hansen F, Stegger M, Sönksen UW, Hasman H, Hammerum AM. Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Euro Surveill. 2017;22(31):pii=30584. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2017.22.31.30584
Received:07 July 2017; Accepted:28 July 2017
Abstract
A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.
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Keywords: Antibiotics; Drugs Resistance; Colistin; MCR3; E. Coli; Denmark.
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