Novel #mcr3 variant, encoding mobile #colistin #resistance, in an ST131 #Escherichia coli isolate from bloodstream #infection, #Denmark, 2014 (@eurosurveillanc, abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Eurosurveillance, Volume 22, Issue 31, 03 August 2017  / Rapid communication

Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014

L Roer 1 , F Hansen 1 , M Stegger 1 , UW Sönksen 1 , H Hasman 1 , AM Hammerum 1

Author affiliations: 1. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark

Correspondence: Louise Roer (loro@ssi.dk)

Citation style for this article: Roer L, Hansen F, Stegger M, Sönksen UW, Hasman H, Hammerum AM. Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Euro Surveill. 2017;22(31):pii=30584. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2017.22.31.30584

Received:07 July 2017; Accepted:28 July 2017

 

Abstract

A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.

Keywords: Antibiotics; Drugs Resistance; Colistin; MCR3; E. Coli; Denmark.

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Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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