[Source: Immunity & Ageing, full page: (LINK). Abstract, edited.]
SHORT REPORT / OPEN ACCESS
Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus
Birgit Weinberger, Michael Keller and Beatrix Grubeck-Loebenstein
Immunity & Ageing – 201714:16 – DOI: 10.1186/s12979-017-0099-y
© The Author(s). 2017
Received: 1 March 2017 – Accepted: 19 June 2017 – Published: 26 June 2017
Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed controversially. We have demonstrated that recall responses to diphtheria vaccination are frequently insufficient in elderly persons and that antibody concentrations decline substantially within 5 years. In the current study we show that within a cohort of healthy elderly (n = 87; median age 71 years, range 66–92) antibody responses to a booster vaccination against diphtheria do not differ between CMV-negative and CMV-positive individuals 4 weeks after vaccination.. However, the goal of diphtheria-vaccination is long-term protection and this is achieved by circulating anti-toxin antibodies. Diphtheria-specific antibody concentrations decline faster in CMV-positive compared to CMV-negative older adults leading to an increased proportion of persons without protective antibody concentrations 5 years after booster vaccination and endangering long-term protection. This finding could be relevant for vaccination schedules.
Keywords: Cytomegalovirus – Diphtheria – Antibody maintenance – Elderly
Keywords: Cytomegalovirus; Diphtheria; Vaccines.