#Management and #outcomes of severe #dengue #patients presenting with #sepsis in a #tropical country (PLoS One, abstract)

[Source: PLoS One, full page: (LINK). Abstract, edited.]


Management and outcomes of severe dengue patients presenting with sepsis in a tropical country

Prapit Teparrukkul, Viriya Hantrakun, Nicholas P. J. Day, T. Eoin West, Direk Limmathurotsakul

Published: April 24, 2017 / https://doi.org/10.1371/journal.pone.0176233




Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management and outcomes of dengue patients presenting with sepsis in a prospective study of community-acquired sepsis in Thailand.


From June to December 2015, 874 adult patients (age≥18 years) with suspected or documented community-acquired infection, with ≥3 diagnostic criteria for sepsis according to the Surviving Sepsis Campaign 2012, and within 24 hours of admission were evaluated. Serum was stored and later tested for dengue PCR assays.


A total of 126 patients had dengue PCR assays positive (2 DENV-1, 12 DENV-2, 24 DENV-3 and 88 DENV-4), and 5 of them (4%) died. We found that attending physicians suspected dengue infection on admission in 84 patients (67%), and recorded dengue infection as the final diagnosis in 96 patients (76%). Four of five fatal cases were diagnosed and treated as septic shock not due to dengue. In multivariable analysis, there was a trend showing that age≥60 years, hypoxemia and misdiagnosis of dengue by attending physicians were associated with 28-day mortality.


A number of adult patients who died of dengue are misdiagnosed as severe sepsis and septic shock. Diagnosis of dengue based on clinical features alone is difficult. Rapid diagnostic tests for dengue may need to be routinely used in adult patients presenting with sepsis and septic shock in tropical countries. This approach could improve diagnosis and management of those patients.


Citation: Teparrukkul P, Hantrakun V, Day NPJ, West TE, Limmathurotsakul D (2017) Management and outcomes of severe dengue patients presenting with sepsis in a tropical country. PLoS ONE 12(4): e0176233. https://doi.org/10.1371/journal.pone.0176233

Editor: Nguyen Tien Huy, Institute of Tropical Medicine (NEKKEN), Nagasaki University, JAPAN

Received: January 9, 2017; Accepted: April 8, 2017; Published: April 24, 2017

Copyright: © 2017 Teparrukkul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: All relevant data are available from figshare at: https://figshare.com/s/a31da6384a6a50c99464.

Funding: The prospective sepsis study was funded by the Wellcome Trust (106698/B/14/Z) and National Heart, Lung and Blood Institute, National Institutes of Health (R01HL113382). The dengue PCR assays were funded by Defense Threat Reduction Agency, USA (W911QY-16-C-0017). DL is supported by an intermediate fellowship from the Wellcome Trust (101103/Z/13/Z).

Competing interests: The authors have declared that no competing interests exist.

Keywords: Dengue Fever; Sepsis.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.