#ICAM-5/Telencephalin Is a Functional Entry #Receptor for #Enterovirus #D68 (Cell Host Microbe, abstract)

[Source: Cell Host & Microbe, full page: (LINK). Abstract, edited.]

ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68

Wei Wei, Haoran Guo, Junliang Chang, Yingzi Yu, Guanchen Liu, Nannan Zhang, Stephen H. Willard, Shu Zheng, Xiao-Fang Yu5

5Lead Contact

Publication stage: In Press Corrected Proof / DOI: http://dx.doi.org/10.1016/j.chom.2016.09.013

Publication History

Published: October 27, 2016 – Accepted: September 21, 2016 – Received in revised form: August 5, 2016 – Received: May 13, 2016

 

Highlights

  • ICAM-5 expression is associated with host cell susceptibility to EV-D68
  • EV-D68 viruses bind specifically to ICAM-5
  • Soluble ICAM-5 fragments efficiently inhibit EV-D68 infection in vitro and in vivo
  • ICAM-5 mediates viral infection of prototype Fermon and circulating EV-D68 strains

 

Summary

Enterovirus D68 (EV-D68) is a member of the Picornaviridae family. Although EV-D68-associated infection was once considered rare, it has been increasing in recent years. EV-D68 infection is most frequently associated with respiratory illness. However, it has also been implicated in a polio-like neurological disorder, acute flaccid myelitis. Although sialic acid has been implicated in EV-D68 entry, the existence of a protein receptor has yet to be clarified. Here we identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent EV-D68 viruses. EV-D68 bound specifically and efficiently to ICAM-5, and replication of EV-D68 in diverse cell types was inhibited by soluble ICAM-5 fragments. ICAM-5 silencing attenuated EV-D68 replication in permissive cells, and ICAM-5 expression in non-permissive cells allowed EV-D68 replication. The discovery of a neuron-specific adhesion molecule as an EV-D68 receptor has important implications for EV-D68 pathogenesis and may facilitate the development of novel intervention strategies.

Keywords: EV-D68, ICAM-5/telencephalin, entry receptor, acute flaccid myelitis, enterovirus, picornaviridae, respiratory illness

Received: May 13, 2016; Received in revised form: August 5, 2016; Accepted: September 21, 2016; Published: October 27, 2016

© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

Keywords: EV-D68; Acute Flaccid Myelitis; Picornavirus.

——

Published by

Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.