#Bacteriocin #production: a relatively unharnessed #probiotic trait? (F1000 Res., abstract)

[Source: F1000 Research, full page: (LINK). Abstract, edited.]


Bacteriocin production: a relatively unharnessed probiotic trait? [version 1; referees: 2 approved]

James W. Hegarty1,2, Caitriona M. Guinane1, R. Paul Ross1,3, Colin Hill2,3, Paul D. Cotter1,3

Author affiliations: 1 Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland; 2 Department of Microbiology, University College Cork, Cork, Ireland; 3 APC Microbiome Institute, University College Cork, Cork, Ireland

Grant information: This work was funded by a Science Foundation Ireland award “Obesibiotics” (11/P1/1137) to PDC.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.



Probiotics are “live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host”. A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.


Corresponding author: Paul D. Cotter

How to cite: Hegarty JW, Guinane CM, Ross RP et al. Bacteriocin production: a relatively unharnessed probiotic trait? [version 1; referees: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):2587 (doi: 10.12688/f1000research.9615.1)

Copyright: © 2016 Hegarty JW et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests: The authors declare that they have no competing interests.

First published: 27 ott 2016, 5(F1000 Faculty Rev):2587 (doi: 10.12688/f1000research.9615.1)

Latest published: 27 ott 2016, 5(F1000 Faculty Rev):2587 (doi: 10.12688/f1000research.9615.1)

Keywords: Baceriocin.


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I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.