Methodological #evolution of #influenza #vaccine #effectiveness #assessment (The Lancet ID., abstract)

[Source: The Lancet Infectious Diseases, full page: (LINK). Summary.]

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Methodological evolution of influenza vaccine effectiveness assessment

James E Fielding

Published Online: 06 April 2016 / Article has an altmetric score of 10 / DOI: http://dx.doi.org/10.1016/S1473-3099(16)00155-9

 

Summary

Over the last 10 years, the case test-negative study (or test-negative design) has emerged as the preferred observational study design from which to calculate influenza vaccine effectiveness (VE). From humble beginnings as a sentinel physician pilot project in Canada in 2004–05,1 it is now used as far afield as China,2 South Africa,3 and Central America.4 It is a prospective variant of the traditional case-control study design, in which the case (test positive) or control (test negative) status of the study participants is not known at the time of their recruitment into the study: patients presenting with a defined acute respiratory illness are tested for influenza and those who test positive become cases and those who test negative become controls.

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Keywords: Research; Abstracts; Seasonal Influenza; Vaccines.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.